Blaine Scully will captain USA Rugby as they kick-off their Americas Rugby Championship campaign against Uruguay.
The wing has been in fine form for Cardiff Blues this season and will feature in the Toyota Field clash before returning to Wales’ Capital Region.
Uruguay have won just two of their 15 meetings with the Eagles since 1989, the most recent victory a home win last March.
In 10 tests since, Los Teros have outscored opponents 230-220 despite winning on only four occasions.
"It'll be a tight contest because both sides enjoy moving the ball," Mitchell said.
"They're a team that flat-out plays at 110 miles per hour. I still think it'll come down to who's most disciplined and who is the best - defensively - on the evening."
The first international test rugby match in San Antonio will kick off from Toyota Field Saturday, Feb. 4, at 3 p.m
USA Rugby: Mike Te’o; Blaine Scully (capt), Bryce Campbell, AJ McGinty, Zack Test; Ben Cima, Nate Augspurger; Anthony Purpura, Peter Malcolm, Chris Baumann, Nate Brakeley, Nick Civetta, John Quill, Todd Clever, Al McFarland.
Replacements: James Hilterbrand, Alex Maughan, Dino Waldren, Matthew Jensen, Tony Lamborn, Shaun Davies, Will Magie, JP Eloff