Cardiff Blues kick start their European campaign with a trip to northern Italy to take on Rugby Calvisano.
John Mulvihill has made a total of eight changes for the clash, as Wales' Capital Region return to Challenge Cup action for the first time since that unforgettable evening in Bilbao in 2018.
Will Davies-King, James Ratti and Ben Thomas are all in-line to make their first senior appearances for the region.
Cardiff Blues: Matthew Morgan; Jason Harries, Rey Lee-Lo, Willis Halaholo, Harri Millard; Jarrod Evans, Lewis Jones; Brad Thyer, Kirby Myhill, Keiron Assiratti, Josh Turnbull (capt), Macauley Cook, Shane Lewis-Hughes, James Botham, Seb Davies
Replacements: Ethan Lewis, Rhys Gill, Will Davies-King, James Ratti, Alun Lawrence, Lloyd Williams, Dan Fish, Ben Thomas
Rugby Calvisano: Kayle van Zyl; Simone Balocchi, Giacomo De Santis, Damiano Mazza, Marco Susio; Paolo Pescetto, Federico Consoli; Riccardo Brugnara, Gabriele Morelli (capt), Lorenzo Cittadini, Adam Wessels, Mike van Vuren, Matteo Archetti, Nardo Casolari, Samu Vunisa
Replacements: Matteo Luccardi, Lorenzo Michelini, Piermaria Leso, Gabriele Venditti, Antoine Koffi, Fabio Semenzato, Alberto Chiesa, Facundo Panceyra-Garrido
From the Vault: Calvisano 10 Cardiff Blues 25
It was a packed house in Calvisano in 2005 as one of world rugby's true global superstars, Jonah Lomu, made his debut for Wales' Capital Region.
The All Blacks legend lined up for his first competitive appearance in three years and proved a handful, despite not finding the whitewash.
The Blues ran out comfortable winners thanks to tries from Chris Czekaj, Robert Sidoli, Rhys Williams and Martyn Williams.
Italian internationals Paul Griffen and Martin Castrogiovanni were amongst those lining up for the hosts.
Head-to-Head: Kayle van Zyl vs Matthew Morgan
South African-born full back, van Zyl, made the switch to Italian rugby back in 2014, after a stint with Southern Kings.
He has previous experience in both Guinness PRO14 and European rugby from his time with Zebre, and in fact scored his first try for the Parma outfit against Cardiff Blues.
Matthew Morgan has enjoyed a good run of form this season, impressing with his defensive and aerial duties and typically being a menace in attack.