The Blues slipped to a frustrating defeat to the Scarlets on New Year’s Day but have another opportunity to make up ground on the Guinness PRO12 top six in Scotland.
Glasgow currently sit fifth in PRO12 table and nine-points ahead of Danny Wilson’s men.
Wales’ Capital Region defeated Gregor Townsend’s men 23-19 in the reverse fixture at BT Sport Cardiff Arms Park earlier in the season.
Wilson has made two changes to the line-up which faced Scarlets at the turn of the year, as Blaine Scully and Anton Peikrishvili return.
USA international Scully has passed return to pay protocols following concussion to replace Rhun Williams on the left wing and Georgia prop Peikrishvili comes in for Taufa’ao Filise after serving his suspension.
Glasgow have made sweeping changes, for what is expected to be a sell-out encounter, nine players come into the starting XV, including international Jonny Gray, who captains his side.
The Warriors go into the game on the back of a four game winning streak, with Ali Price, Finn Russell and centres Alex Dunbar and Mark Bennett also returning to the line-up.
What They Said:
Head coach Danny Wilson said: “We need to pick up league wins to give ourselves a chance to be in that top six. Glasgow will be another tough challenge in a short six-day turn around, but one we will relish.
“If we can play with the hunger and passion we played with in the two derbies and the physicality, it will give us a chance.
“We need to be more accurate with the opportunities we get, but I’m certainly seeing some areas of our game building and improving over the last month.
“Gregor Townsend has done a fantastic job at Glasgow and at their place, with the style of rugby they’re playing, it will be a big challenge.
"They play on the same surface we do. If we can be somewhere we've been recently defensively, it gives us a good chance to cause an upset."
Meanwhile, back-row Ellis Jenkins has called on his side to unleash their frustrations against Glasgow Warriors, following the derby day defeat at Parc y Scarlets.
Jenkins believes his side created enough chances to win the game against Scarlets, but need to be more clinical if they are to hit their target of a top six finish.
"It was frustrating. We felt that we created enough chances to win the game. We had 10 line-breaks and scored one try, which is criminal at this level," said the Welsh international.
"It's all about the small margins. We've spoken a lot this week about being more clinical. Unfortunately it was the same out in Connacht, at home to Leinster. The best teams get to the twenty-two and come away with points.
"That's where we need to build ourselves. We are creating the chances, which is encouraging, but ultimately if you don't convert those chances you're going to struggle.
“Our challenge is to go up to Glasgow and make it as tough for them as we can. They play on the same pitch as us so that's something we'll be used to and it will be about playing our game and not playing into their hands.
"We have to focus on ourselves, make sure we get ourselves right, mentally and physically.
"It was well documented last season that we didn't travel well, but we've improved on that a little bit this year, but they'll want revenge from the fixture earlier in the season, so hopefully it will be a good game on Saturday.
"It's another opportunity to go up against a team that's near us in the table and climb our way back up.
"Glasgow play an expansive game of rugby, and we took that away from them very well at home. Our challenge will be to do that again a not play the game they want to play.”
Peter Murchie, Tommy Seymour, Mark Bennett, Alex Dunbar, Lee Jones, Finn Russell, Ali Price, Gordon Reid, Pat MacArthur, D'arcy Rae, Tim Swinson, Jonny Gray (capt), Josh Strauss, Simone Favaro, Ryan Wilson.
James Malcolm, Alex Allan, Zander Fagerson, Rob Harley, Adam Ashe, Grayson Hart, Rory Clegg, Sean Lamont.
Matthew Morgan; Alex Cuthbert, Rey Lee-Lo, Willis Halaholo, Blaine Scully; Steven Shingler, Lloyd Williams; Rhys Gill, Kristian Dacey, Anton Peikrishvili, Macauley Cook, James Down, Ellis Jenkins, Sam Warburton (capt), Josh Navidi
Matthew Rees, Brad Thyer, Scott Andrews, Jarrad Hoeata, BJ Edwards, Tomos Williams, Nicky Robinson, Rhun Williams