Scarlets are the visitors to Cardiff Arms Park for the final festive derby of the campaign.
Cardiff Blues head into the encounter following back-to-back victories over Ospreys and Dragons, and will be targeting a Christmas clean sweep before they head back into European action.
While Scarlets suffered a last-gasp defeat to Dragons at Rodney Parade, following a dramatic Sam Davies drop goal, they bounced back in style to thump bitter rivals Ospreys at Parc y Scarlets on Boxing Day.
Cardiff Blues: Hallam Amos; Owen Lane, Rey Lee-Lo, Ben Thomas, Josh Adams; Jarrod Evans, Tomos Williams; Rhys Gill, Liam Belcher, Scott Andrews, Filo Paulo, Josh Turnbull, Josh Navidi (capt), Will Boyde, Nick Williams
Replacements: Ethan Lewis, Corey Domachowski, Keiron Assiratti, James Ratti, Olly Robinson, Lloyd Williams, Jason Tovey, Matthew Morgan
Scarlets: Leigh Halfpenny; Ryan Conbeer, Steff Hughes, Hadleigh Parkes, Steff Evans; Angus O'Brien, Gareth Davies; Wyn Jones, Ken Owens (capt), Werner Kruger, Jake Ball, Tevita Ratuva, Aaron Shingler, Josh Macleod, Uzair Cassiem
Replacements: Ryan Elias, Phil Price, Samson Lee, Sam Lousi, Blade Thomson, Kieran Hardy, Ryan Lamb, Paul Asquith
From the Vault: Cardiff Blues 41 Scarlets 17 (2018/19)
A devastating first-half performance blew the Scarlets away as Cardiff Blues completed a Guinness PRO14 double over their Welsh rivals with a stunning 41-17 victory at the Arms Park.
Following a 34-5 victory at Parc y Scarlets in the previous December, Wales’ Capital Region ran riot once again. They crossed for five tries in a dominant first half thanks to Owen Lane, Aled Summerhill and Josh Turnbull.
The Scarlets hit-back early in the second-half thanks to Rob Evans and dominated for long periods but John Mulvihill’s were virtually home and dry.
Evans’ impressive impact from the bench continued with a second try, but Anscombe struck a late penalty to surpass the 40-point mark.
Ioan Nicholas added a third for the visitors, as he intercepted Rhys Carre deep in the 22, but they were unable to secure a bonus point of their own as Cardiff Blues continued to defend heroically in the final moments.
Head-to-Head: Tomos Williams v Gareth Davies
It is set to be a mouth-watering battle at scrum half as Wales international contenders, Tomos Williams and Gareth Davies, go head-to-head.
Both players are amongst the PRO14's most dangerous attacking number nines, and possess the ability to be true game-changers when on form.
Williams has been in blistering form this season, whether it's been as an impact sub for Wales during the World Cup or pulling the strings since returning to regional action.