Tongan ace Filise – already the leading appearance maker for Cardiff Blues - will bring up his landmark 200 games while a trio of star Wales internationals also make a comeback.
Head Coach Danny Wilson makes a total of seven changes to the side that started against Zebre last weekend.
Gethin Jenkins is back to captain the team at loosehead prop while another change in the front row sees a return for hooker Kristian Dacey.
The other change in the pack is a call-up for Wales international captain Sam Warburton to the back row for his first appearance of the season in the seven jersey. Josh Turnbull will operate at Number Eight and Ellis Jenkins at blindside flanker.
A new midfield partnership will see fit-again Gavin Evans play at inside centre while Samoa international Rey Lee-Lo will make his debut for Cardiff Blues on home soil. The final change to the side is a return for wing Alex Cuthbert.
Lock Jarrad Hoeata is named among the replacements with Jarrod Evans rewarded for his eye-catching performance for the Cardiff Blues Premiership Select with a spot on the bench.
Josh Navidi (neck), Cam Dolan (hamstring), Gareth Anscombe (foot) and Cory Allen (hamstring) all miss the fixture.
Wilson said: “It’s fantastic to be coming home after two months away from BT Sport Cardiff Arms Park and we’re looking forward to the clash with Glasgow Warriors.
“Our opening day victory over Zebre was a special occasion and it’s vital we make our home a difficult place for any team to visit.
“Glasgow are a very talented side, who showed last weekend against Ospreys what they are capable of. Gregor Townsend and his coaching team have done a fantastic job over the last few years and they are the model for many teams to follow.
“We’re delighted to welcome back our Welsh internationals and Rey Lee-Lo will also make his home debut.
“While Rey will make his first appearance we have Taufa’ao Filise making his 200th
appearance which is a staggering feat.
“To play that many games for a team is a wonderful achievement and testament to his dedication and durability. We congratulate him on this special milestone.”
Cardiff Blues: 15 Dan Fish, 14 Alex Cuthbert, 13 Rey Lee-Lo, 12 Gavin Evans, 11 Tom James, 10 Rhys Patchell, 9 Lloyd Williams; 1 Gethin Jenkins (c), 2 Kristian Dacey, 3 Taufa’ao Filise, 4 Lou Reed, 5 James Down, 6 Ellis Jenkins, 7 Sam Warburton, 8 Josh Turnbull
Replacements: 16 Matthew Rees, 17 Sam Hobbs, 18 Craig Mitchell, 19 Jarrad Hoeata, 20 Manoa Vosawai, 21 Tavis Knoyle, 22 Jarrod Evans, 23 Tom Isaacs