In the backs the Blues bring in Dafydd Hewitt to the centre with Gavin Evans moving to the bench and Richie Rees starting at scrum half with Lewis Jones also moving to the bench.
There is one change to the forwards with young openside Thomas Young starting. Mamma Molitika moves to blindside with Michael Paterson in the second row in place of Deiniol Jones who moves to the bench.
The Blues will be looking to get back to winning ways, having recorded three successive defeats, the region’s worst run since 2009. They face an Aironi side who won their most recent home game in the RaboDirect PRO12, 25-19, over Edinburgh in round four
Cardiff Blues took both encounters last season, and have never lost in ten previous matches against Italian teams.
The game played at the Stadio Zaffanella, which kicks off at 2pm UK time, is not televised but live updates can we found on www.rabodirectpro12.com/
15. Chris Czekaj 14. Alex Cuthbert 13. Casey Laulala 12. Dafydd Hewitt 11. Tom James 10. Ceri Sweeney 9. Richie Rees
8. Xavier Rush 7. Thomas Young 6. Maama Molitika 5. Paul Tito (c) 4. Michael Paterson 3. Scott Andrews 2. Rhys Williams 1. Sam Hobbs
16. Ryan Tyrrell17. Nathan Trevett 18. Ryan Harford 19. Deiniol Jones 20. Luke Hamilton 21. Lewis Jones 22. Gareth Davies 23. Gavin Evans